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TUESDAY, Jan. 19, 2021 — For sufferers with COVID-19 within the intensive care unit (ICU), mortality is related to COVID-19 ICU pressure, based on a research printed on-line Jan. 19 in JAMA Community Open.

Daybreak M. Bravata, M.D., from the Well being Providers Analysis and Improvement Heart for Well being Info and Communication in Indianapolis, and colleagues examined whether or not COVID-19 mortality is related to COVID-19 ICU pressure in a cohort research performed amongst 8,516 veterans with COVID-19 admitted to 88 Veterans Affairs hospitals.

The researchers discovered that mortality different over time, with 22.9, 25.0, 15.5, 13.6, 12.5, and 12.Eight p.c of sufferers dying in March, April, Might, June, July, and August, respectively. In contrast with sufferers handled in periods of low COVID-19 ICU demand, these handled within the ICU in periods of elevated COVID-19 ICU demand had elevated mortality (adjusted hazard ratio for all-cause mortality, 0.99 [95 percent confidence interval, 0.81 to 1.22; P = 0.93] for sufferers handled when demand was >25 to 50 p.c; 1.19 [95 percent confidence interval, 0.95 to 1.48; P = 0.13] when demand was >50 to 75 p.c; and 1.94 (95 p.c confidence interval, 1.46 to 2.59; P < 0.001] when demand was >75 to 100 p.c). For sufferers with COVID-19 not within the ICU, no affiliation was seen between COVID-19 ICU demand and mortality. The affiliation between COVID-19 ICU load and mortality different over time.

“Public well being officers and hospital directors might search to forestall excessive COVID-19 ICU demand to optimize outcomes for sufferers with COVID-19,” the authors write.

One creator disclosed monetary ties to the pharmaceutical trade.

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Posted: January 2021

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