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‘Catastrophic’ Breeding Failure at One in every of World’s Largest Emperor Penguin Colonies


Emperor penguins on the Halley Bay colony within the Weddell Sea have failed to lift chicks for the final three years, scientists have found.

Researchers from British Antarctic Survey (BAS) studied very excessive decision satellite tv for pc imagery to disclose the weird findings, printed right this moment April 25, 2019 within the journal Antarctic Science.

Till just lately, the Halley Bay colony was the second largest on the planet, with the variety of breeding pairs various annually between 14,000 – 25,000; round 5 to 9 p.c of the worldwide emperor penguin inhabitants.

The failure to lift chicks for 3 consecutive years is related to modifications within the native sea-ice situations. Emperor penguins want steady sea-ice on which to breed, and this icy platform should final from April when the birds arrive, till December when their chicks fledge.

For the final 60 years the sea-ice situations within the Halley Bay website have been steady and dependable. However in 2016, after a interval of abnormally stormy climate, the sea-ice broke up in October, properly earlier than any emperor chicks would have fledged.

This sample was repeated in 2017 and once more in 2018 and led to the loss of life of virtually all of the chicks on the website every season.

The colony at Halley Bay colony has now all however disappeared, while the close by Dawson Lambton colony has markedly elevated in measurement, indicating that most of the grownup emperors have moved there, searching for higher breeding grounds as environmental situations have modified.

The re-location of most of the birds to a extra steady breeding floor is encouraging, as till now it was not identified whether or not the penguins would search different websites in response to vital modifications of their native surroundings.

Lead writer and BAS distant sensing specialist Dr. Peter Fretwell mentioned: “We’ve got been monitoring the inhabitants of this, and different colonies within the area, for the final decade utilizing very excessive decision satellite tv for pc imagery.

“These photos have clearly proven the catastrophic breeding failure at this website over the past three years. Our specialised satellite tv for pc picture evaluation can detect people and penguin huddles, so we will estimate the inhabitants based mostly on the identified density of the teams to present dependable estimate of colony measurement.”

BAS penguin professional and co-author Dr. Phil Trathan, mentioned: “It’s unattainable to say whether or not the modifications in sea-ice situations at Halley Bay are particularly associated to local weather change, however such a whole failure to breed efficiently is unprecedented at this website.

“Even bearing in mind ranges of ecological uncertainty, printed fashions counsel that emperor penguins numbers are set to fall dramatically, dropping 50-70 p.c of their numbers earlier than the tip of this century as sea-ice situations change on account of local weather change.”

Through the use of satellite tv for pc imagery to review the conduct of this colony and its response to catastrophic sea-ice loss scientists will achieve important details about how this iconic species would possibly address future environmental change.

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Polyacrylamide Gel Electrophoresis | Lab Supervisor


Polyacrylamide gel electrophoresis is a molecular biology method that allows separation of proteins or nucleic acids. Totally different approaches to gel electrophoresis facilitate the separation of molecules based mostly on their higher-order construction, molecular weight, or isoelectric level and molecular weight in two dimensions.

 

 

 

Obtain the total infographic, compliments of LabCups.

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Options for Laboratory Automation | Lab Supervisor


Laboratory automation applied sciences provide the power to increase a lab’s capability whereas on the identical time elevating experimental knowledge high quality and reproducibility. Laboratories targeted on actions corresponding to high-throughput screening, combinatorial chemistry, automated diagnostics, or large-scale pattern storage may merely not operate with out the advantage of superior automated devices and applied sciences.

BRAND LHS Liquid Dealing with Station

The BRAND LHS Liquid Dealing with Station pipetting robotic handles routine duties at excessive pace and with the very best precision. The LHS closes the hole between digital pipettes and extremely advanced, costly pipetting robots. It’s a quiet and compact instrument with a singular entrance door permitting or not it’s arrange in tight quarters. The instrument has 7 working positions and 5 out there liquid ends with single channel volumes as much as 1000uL and multichannel volumes as much as 300uL.

INTEGRA: ASSIST PLUS Pipetting Robotic

INTEGRA’s ASSIST PLUS pipetting robotic is designed to supply distinctive flexibility, with out the necessity for devoted personnel or advanced programming. Utilizing any VOYAGER adjustable tip spacing pipette or VIAFLO digital multichannel pipette, this compact system presents laboratory automation at an inexpensive value, offering reproducible and error-free processing whereas eliminating repetitive handbook pipetting duties.

TECAN: FLUENT® GX Laboratory Automation Workstation

FLUENT® GX was designed to satisfy the wants of varied life science workflows, corresponding to excessive throughput genomics, by combining excessive precision liquid dealing with – all the way down to 200 nl – with easy set-up of normalization, pattern switch, and reagent distribution utilizing Good Instructions. Its freely configurable structure permits speedy integration of units for DNA quantification and processing and presents distinctive storage capability for plates and ideas.

Elemental Machines: Parts

Your Related Platform for Accelerating Science

Mixture knowledge out of your enterprise property by way of our IoT platform. Get real-time metrics for instrument efficiency, utilization, and out-of spec circumstances. Combine knowledge with ELNs, LIMS, and ERP programs.

Labcyte: Echo® 650 Collection Liquid Handlers

One other Step Ahead for Acoustic Liquid Dealing with

Echo® 650 Collection Liquid Handlers signify essentially the most versatile devices for acoustic liquid dealing with. Switch from acoustic pattern tubes with high- and medium-throughput processing speeds with the Echo 655T and 650T, respectively, or from Echo® Certified Microplates and improve to switch from acoustic pattern tubes with Echo 655 and 650.

Automated Mortar Grinder, Pulverisette 2, by Fristch

Common laboratory grinder for evaluation, supplies testing, mixing, and homogenisation of pastes/lotions. Mild motion, nearly no thermal load advantages preparation of even temperature delicate supplies. LN2 permits difficult-to-mill samples to be lowered to powder. Temporary, reproducible grinding/mixing instances enhance person security, strategies, and SOPs for accuracy & effectivity. Fineness of 10-20μm, feed dimension of 6-Eight mm, max pattern amount as much as 190ml.

BioTek™: BioSpa Eight Automated Incubator

BioSpa™ Eight Automated Incubator hyperlinks BioTek readers and imagers along with washers and dispensers for full workflow automation of as much as Eight microplates or different labware. BioSpa Eight can automate your workflows, from ELISA to long run stay cell assays. Temperature and CO2/O2 management, plus humidity monitoring and lid dealing with guarantee an excellent setting for cell cultures throughout all experiment levels, with minimal handbook intervention. BioSpa’s software program information and experiences session timelines and environmental circumstances, whereas customizable textual content and e-mail alerts guarantee confidence throughout long- and short-term runs. Hyperlink a washer or dispenser and a plate reader or imager for start-to-finish workflow automation.

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Cryogenic security hazards | Lab Supervisor


Cryogenic supplies are utilized in all kinds of laboratories. They’re widespread in chemistry, healthcare, and physics labs, and have gotten extra prevalent as stem cell, nanotechnology, pc chip design, and cryotube analysis advance.

Cryogenic fluids are liquefied gases that should be stored at extraordinarily low temperatures. Boiling factors for these gases are often under -150°C (-238°F). For this text, we’ll take into account supplies with boiling factors under -75°C as cryogenic (in order to incorporate dry ice).1 Resulting from its bodily properties, a really small quantity of the liquid can broaden into a really giant quantity of gasoline.

The most typical cryogens embody helium, hydrogen, nitrogen, and oxygen. You’ll encounter them each day when you obtain shipments full of dry ice, protect samples with liquid nitrogen, take away impurities with chilly traps or baths, or hold tools cooled. All these duties might be performed safely if we acknowledge the hazards and endeavor to regulate them. Ought to we turn out to be cavalier, issues can go very mistaken. Listed here are a number of examples:

A laboratory assistant died and 4 different folks have been injured from a chemical leak at a hospital in Edinburgh, Scotland. The assistant died after liquid nitrogen spilled in a basement storage room.2 A college investigator was blinded in a single eye when a cryotube exploded whereas being thawed. The possible explanation for the explosion was the fast growth of liquid nitrogen that had entered the tube by way of a small crack throughout storage.3 A researcher at a college reported {that a} vial of doubtless infectious supplies “exploded” when she eliminated it from liquid nitrogen. The “explosion” occurred when the liquid nitrogen leaked right into a vial and expanded when faraway from the chilly.3

Typically, cryogens current comparable hazards as compressed gases. The first hazards fall into two classes: physiological and bodily.

Physiological Hazards

Physiological hazards produce bodily hurt and are divided into two principal classes—those who injury tissue from direct contact and people that may trigger asphyxiation.

Direct contact

Cryogenic supplies movement freely simply as different liquids do and, in consequence, might splash and spill. The impact produced from unintentional splashes or contact with extraordinarily chilly cryogens is much like liquid nitrogen utilized by your dermatologist. Direct contact with liquid nitrogen or different cryogens freezes and kills tissue quickly.

Asphyxiation

Cryogenic liquids comprise an incredible quantity of potential gasoline quantity. One-unit quantity of liquid nitrogen, for instance, will broaden to supply nearly 700 instances the amount of gasoline when vaporized. This fast and excessive growth can result in oxygen displacement. A leak or vessel breakage can lead to an oxygen-deficient environment fairly rapidly, particularly in small areas with poor air flow.

Bodily Hazards

Bodily hazards embody explosion dangers from stress buildup and people from chemical reactions or combustion.

Explosion—stress

As talked about above, the gasoline quantity generated from the vaporization of the liquid part could be very giant. If this part change happens in a vessel unable to comprise the stress exerted, it might probably fail catastrophically from over-pressurization.

Associated Article: Protected Dealing with of Liquid Nitrogen

Explosion—chemical

Cryogenic fluids with a boiling level under that of liquid oxygen, resembling nitrogen, are in a position to condense and accumulate oxygen from the environment. Violent reactions—for instance, fast combustion or explosion— might happen if incompatible supplies, resembling most typical natural compounds, are available in contact with the oxygen.

Accident Prevention

Anybody who handles or makes use of cryogenic liquids will need to have enough information of the actual materials’s properties and protected dealing with practices.Four Particular understanding acquired by way of correct coaching ought to embody:

Properties of the cryogen as a liquid, strong, or gasoline Supplies suitable to be used with that cryogen (e.g., suitable with the temperatures and pressures of the fabric) Protecting tools required and its correct use Understanding of the tools getting used, together with its security gadgets Emergency procedures, together with first assist and therapy

Guarantee all staff dealing with and utilizing cryogens learn and perceive the security knowledge sheet. As well as, develop and observe commonplace working procedures (SOPs) at any time when dealing with or utilizing cryogenic supplies. To jumpstart your coaching and SOPs, listed below are some fast ideas:

Take away metallic jewellery/watches in your palms and wrists earlier than working with cryogens. If uncovered to cryogenic liquids or boil-off gases, the jewellery can freeze to your pores and skin. Defend your eyes by carrying security goggles at any time when working with cryogenic fluids or samples lately faraway from cryogenic temperatures. Full face shields needs to be used within the following conditions: a) when a cryogen is poured; b) for open transfers; c) if fluid in an open container is prone to bubble. Put on a cryogen apron when working with cryogenic liquids. Attempt to cowl all uncovered pores and skin by carrying long-sleeved shirts, lengthy pants/skirts, a long-sleeved lab coat, well-fitted leather-based footwear (no sneakers), and gloves. Gloves needs to be loosefitting, light-weight, versatile, and insulated in order that they are often rapidly eliminated if cryogenic fluids are spilled on them. Don’t switch liquefied gases from one tank to a different the primary time with out supervision. Use care when filling transportable dewars and don’t overfill them. Switch or pour cryogens slowly in an effort to decrease boiling and splashing. To cut back the quantity of splatter when transferring cryogenic liquids from one container to a different, all the time begin slowly, permitting the vaporization to relax the receiving container earlier than filling it. Use a part separator or particular filling funnel (the highest of the funnel needs to be partly coated to scale back splashing). If the liquid can’t be poured, use a cryogenic liquid withdrawal gadget for the switch (make sure you observe all directions supplied with the gadget). Use tubes particularly designed for cryogenic storage and place them in a heavy-walled container or behind a security protect whereas thawing. When hand-carrying a cryogen-containing dewar, make sure that it’s your solely load (no books, espresso, or different gadgets). Watch fastidiously for individuals who might run into you, and make sure that the dewar is carried with each palms and as distant out of your face as comfortably attainable. Guarantee dewars are correctly labeled with the identification of the cryogen. Don’t combine totally different cryogens. To keep away from asphyxiation, an oxygen monitor in good working order is really helpful in case you are working with a cryogen in a confined area. Don’t allow smoking or open flame in any space the place oxygen or hydrogen is saved, dealt with, or used. Don’t lubricate oxygen tools with oil, grease, or unapproved lubricants. References:

1. Prudent Observe within the Laboratory: Dealing with and Disposal of Chemical substances, Nationwide Academies Press, Nationwide Useful resource Council, Washington, DC. 1995.  

2. “Inquiry after man dies in chemical leak,” BBC On-line Information, Monday, October 25, 1999.  

3. “Lab Security Cryogens Incidents,” American Industrial Hygiene Affiliation, Laboratory Well being and Security Committee. 2015.  

4. “How Do I Work Safely with Cryogenic Liquids?,” Canadian Middle for Occupational Well being and Security, Hamilton, ON, Canada. 2015.  

Obtain the Infographic: Cryogen and Chilly Storage Security 



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Constructing a Future-Pleasant Lab | Lab Supervisor


The loss of life of the blockbuster drug has compelled a reckoning in laboratory design—one which’s uncovered new pathways to a extra agile, future-friendly lab. We all know the lab of the long run should depart behind outdated conventions, so scientists can extra shortly carry significant therapies to sufferers. It’s clear that dashing up innovation has turn into important to creating analysis and growth (R&D) viable in a time of an ongoing decline in income. The following-generation laboratory should be versatile and simply adaptable to assist scale back R&D prices and allow sooner new product growth.

Blockbuster medicine had been sometimes made in industrial power labs—and industrial-strength measures had been required to reconfigure them as new analysis priorities emerged. Dealing with altering affected person wants and ongoing monetary stress, most biopharmaceutical firms merely now not have the form of time or further funding that main lab redesigns historically require. Nor can firms afford to supply up mediocre area just because it matches a price range. As we speak’s high expertise received’t be impressed by yesteryear’s lab design, nor ought to they be.

It’s clear that life sciences and biopharmaceutical firms want new methods to shorten R&D timelines whereas specializing in price discount and ongoing trade consolidation. R&D returns for big biopharmaceutical companies fell from 10.1 p.c in 2010 to a feeble 3.2 p.c in 2017. What’s been much less clear, till now, is methods to obtain the lofty objective of a shorter, extra productive R&D timeline.

Happily, new approaches to bodily area have emerged that make a real contribution to the trouble, based on “Journey to the Subsequent Gen Lab,” a brand new report by JLL (Chicago, IL). From extra versatile area that promotes agility amidst quickly shifting analysis priorities to tech-driven options that may assist organizations leverage huge information and entice expertise, innovation in lab design can result in extra environment friendly innovation within the work itself.

Following are three lab design tendencies serving to organizations obtain a “sooner, lighter” lab of the long run.

Pattern 1: Designing for flexibility and collaboration

“Eureka!” moments can occur anytime—in contrast to a conventional laboratory transformation. Traditionally, reconfiguring a pharmaceutical or biotech lab to assist analysis for an all-new treatment or treatment has been a time-consuming and costly endeavor. However that’s altering as life sciences firms more and more avoid typical lab designs in favor of versatile areas to maintain up with the tempo of innovation.

Amidst quickly shifting analysis priorities, forwardlooking lab designs are these that may be simply reconfigured to accommodate totally different sorts of analysis and assist scientists carry out their research as shortly as doable. Additionally essential are areas that facilitate inventive interplay with colleagues, ideally with out requiring de-gowning.

As evidenced by JLL analysis, R&D actual property is already changing into extra extremely versatile and multiuse. Though flexibility enhancements carry some upfront price concerns, the flexibility to simply transfer heavy-duty gadgets similar to chemical fume hoods could make R&D extra price environment friendly in the long term.

For instance, cellular benches and unassigned workspaces are getting used to permit for quick modifications in personnel and/or the kind of work being carried out. Some lab designers are putting in retractable electrical cords within the ceiling and technical infrastructure into movable facades so workspaces could be arrange in numerous configurations across the lab flooring, reasonably than being restricted to mounted partitions. One other technique is to construct heavy-duty flooring slabs in laboratory corridors to accommodate periodic strikes of heavy gear.

Pattern 2: Much less moist lab, extra computational science area

Lab samples are now not the one topic worthy of shut evaluation. Due to persevering with advances in information and analytics expertise, in addition to entry to massive information units, drug growth has turn into more and more built-in with information science. With the assistance of cloud computing, researchers can shortly entry, search, and analyze digital well being information and genome analysis for brand new insights. And analytics-fueled analysis comes with lighter regulatory necessities than, say, analysis involving animals or hazardous supplies.

But all that computing requires seats, desks, energy, and area. On account of the rising promise of computational science, moist labs are shrinking to make manner for extra workplace area. By way of lab design, the evolution represents a reasonably vital shift in area utilization when you think about {that a} conventional R&D facility sometimes consists of largely lab area and a comparatively small proportion of workplace area.

The rise of synthetic intelligence, machine studying, and different computing applied sciences in laboratories solely provides gasoline to the fireplace of change. Sooner or later, lab proportions will doubtless shift to equal components moist labs, flex area, and workplace area for information scientists. The shift in analysis modes may additionally assist decision-makers divert funding from delicate lab necessities, similar to bacteriaresistant counter tops and sinks, to state-of-the-art information analytics instruments, similar to digital laboratory notebooks and highly effective pc programs.

Pattern 3: Specializing in expertise recruitment and retention

The struggle for proficient biologists and chemists is ongoing, with no signal of aid in sight with the concurrent stress for extra productive R&D. Including to the stress is the rising competitors for in-demand information scientists to work with at the moment’s voluminous analysis information. Life sciences R&D organizations should compete for information scientists not solely towards the most important expertise firms—whose reputations for providing extremely fascinating workplaces are thought-about by some to be unequalled—but additionally towards firms exterior the expertise sector.

This mandate to draw and retain extra expert expertise is having a ripple impact on main actual property selections, as illustrated in JLL’s “Life Sciences Outlook” report. Biopharmaceutical firms are intensifying their drive to be close to main educational analysis facilities and the supportive R&D ecosystems that encompass them, regardless of the excessive rents of enticing cities like San Francisco, San Diego, and Boston.

Expertise wars are additionally contributing to a rising concentrate on facilities, aesthetic enchantment, state-of-the-art gear, and a spotlight to sustainable design. The darkish labs of yesteryear are giving technique to lab designs that incorporate pure gentle, sustainability options, and enticing sight traces that, ideally, will promote well-being and encourage inventive excited about analysis issues.

Slightly than hiding R&D area deep inside a facility, for instance, some biopharmaceutical firms are creating lab areas on the edges of their amenities to showcase their cutting-edge applied sciences and abundance of pure gentle. Perimeter placement serves the twin goal of attracting new recruits whereas additionally making it simple for senior scientists to pop in after hours or on weekends to verify a take a look at end result—a comfort that may assist increase retention, too.

Collaboration-friendly area particularly generally is a sport changer for organizations trying to spark the curiosity of the subsequent technology of scientists. A lot of at the moment’s science college students reveal a robust need to share concepts with their friends and like areas the place they’ll study as groups, reasonably than in isolation. Ahead-looking R&D organizations are offering comfy, inviting locations for formal and casual collaboration to spark nice concepts.

Sensible expertise can also be changing into a differentiator within the lab office. Some labs are adopting Web of Issues applied sciences—from good security goggles and self-cleaning lab benches to sensor-powered pattern freezers. Offering entry to the newest tech-enabled instruments not solely helps entice new expertise, but additionally may also help workers turn into extra environment friendly and nimble.

The way forward for lab design is flexibility

It’s turn into abundantly clear that versatile lab design and entry to expertise are the keys to agile R&D. By investing in adaptable laboratory options at the moment, a biopharmaceutical firm can place its R&D operations for long-term agility. And funding in sustainable, inspiring design that fosters well-being and makes room for collaboration can additional advance the final word objective of R&D: the subsequent nice breakthroughs.

Is your group prepared for the way forward for R&D? When you’re creating your nextgeneration lab across the wants of each your everchanging analysis priorities and the latest technology of scientists, the reply could possibly be sure.

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The Change You Need in Your Lab


At this time’s laboratory is below unprecedented strain. From elevated regulatory scrutiny to exponentially bigger quantities of knowledge, labs are being known as on to drive smarter choice making and assist with organizational integration.

That’s the place Abbott is available in. Laboratory data administration techniques (LIMS) platforms can play a vital function in tackling information administration challenges, and STARLIMS, Abbott’s web-based LIMS providing, may also help enhance processes all through the complete product lifecycle, from medical trials to manufacturing. Abbott’s new and enhanced STARLIMS Scientific Resolution CL 11.Zero which incorporates the Life Sciences industries of pre-clinical, medical analysis, biorepository, molecular and tutorial analysis, and STARLIMS High quality Manufacturing Resolution QM 11.1, which incorporates the industries of pharmaceutical, biotech, chemical, meals & beverage and petrochemical/refining are constructed on the most recent V. 11.6 of the STARLIMS know-how platform, which was developed to simplify information administration whereas enhancing integration and user-friendliness.

“STARLIMS was designed to empower laboratories all over the world to ship high-quality, secure merchandise to market as rapidly as attainable,” says Mark Spencer, divisional vice chairman and normal supervisor, Informatics, Abbott. “These enhancements to STARLIMS Life Sciences and High quality Manufacturing options replicate Abbott’s ongoing dedication to innovation and assembly buyer wants.”

STARLIMS Scientific Resolution CL 11.0

At this time’s laboratories make main investments in analytical tools, however issues can happen when proprietary instrument software program interfaces instantly with some LIMS.

Due to a brand new partnership between Abbott and Information Innovation, Abbott’s STARLIMS Scientific Resolution CL 11.Zero may also help to alleviate stressors by permitting lab connectivity with a good wider vary of third celebration instrumentation, giving laboratories extra freedom to decide on their instruments based mostly on scientific and enterprise necessities moderately than information system limitations.

STARLIMS Scientific Resolution CL 11.Zero options enhancements that streamline pattern administration, simplify accessioning and permit for interfacing with third celebration devices, together with the conversion to HTML5 net platform. In consequence, labs can function with elevated flexibility, productiveness and effectivity, and cut back the complexities of working with totally different software program platforms.

STARLIMS High quality Manufacturing Resolution QM 11.1

Developed to help laboratory productiveness and effectivity throughout numerous sectors of the worldwide manufacturing trade, STARLIMS High quality Manufacturing Resolution QM 11.1 presents options to assist producers function extra successfully by a real-time, holistic view of workflow progress of their laboratories.

With updates comparable to a brand new request administration portal, a user-friendly and customizable dashboard, and out-of-the-box, pre-aided graphical workflows for 5 key testing lifecycles and mobility purposes, these enhancements not solely present an intuitive visible interface but in addition assist guarantee transparency and help regulatory compliance.

From Scientific Trials, Manufacturing and Past…

The current product enhancements to STARLIMS Life Sciences Resolution CL 11.Zero and STARLIMS High quality Manufacturing Resolution QM 11.1 are user-friendly, adaptable to your group’s wants, and help the quickly altering information administration wants throughout your group.

Discover out extra about STARLIMS options and the way it may also help you are taking your online business to the following degree at